Friday, April 24, 2015

ENDOCRINE SYSTEM

An endocrine gland is a gland without ducts. The secretions are released directly into the 

blood. The endocrine glands secrete hormones that regulate various metabolic activities 

in the body.

Here is a good diagram of the endocrine system. Click here. You can be given a diagram
 like this and you could be asked to identify the various glands.

Hypothalamus: The hypothalamus produces eight (8) hormones. Some of the hormones stimulate
the pituitary gland to produce other hormones.

1. Thyrotropin-releasing hormone - This acts on the pituitary to release thyroid stimulating
 hormone (TSH)
2. Growth hormone-releasing hormone-This acts on the pituitary to release growth hormone (GH)
3. Gonadotropin-releasing hormone -This acts on the pituitary to release gonadotropins, namely,
Follicle stimulating hormone (FSH) and Luteinizing hormone (LH).
4. Corticotropin-releasing hormone -This acts on the pituitary to release adrenocorticotropic
 hormone.
5. Oxytocin -This causes uterine contractions and also helps with secretion of the breast milk
 during lactation.
6. Dopamine - It is a neuroendocrine transmitter. Acts as a neuro-transmitter and also stimulates
 the release of othe hormones.
7. Vasopressin (Antidiuretic hormone -ADH) - Acts on the kidneys to prevent the lost of water
via the urine.
8. Somatostatin - It inhibits the release of growth hormone.

Pituitary gland: Has an anterior (hormone-producing glandular) portion and a
 posterior (neural) portion which is an extension of the hypothalamus.  
Two hormones ( Oxytocin and ADH) produced by the hypothalamus are stored
 in the posterior pituitary later release.
Four of the six pituitary hormones are tropic hormones. They regulate the function
of other endocrine glands.Here are the hormones produced by the anterior portion:
1.  Growth hormone (GH): It stimulates growth of all body tissues but especially
skeletal muscle and bone. GH mobilizes fats, stimulates protein synthesis, and inhibits 
glucose uptake and metabolism. Over production can lead to gigantismwhile 
underproduction can lead to dwarfism.
2. Thyroid-stimulating hormone (TSH): This promotes normal development and activity
 of the thyroid gland. 
3. Adrenocorticotropic hormone (ACTH): This stimulates the adrenal cortex to release
 corticosteroids. 
4. The gonadotropins (follicle-stimulating hormone (FSH) and luteinizing hormone (LH)):
 These regulate the functions of the gonads in both sexes. 
     (a) FSH stimulates sex cell production.  
     (b) LH stimulates gonadal hormone production. 
5. Prolactin (PRL): This promotes milk production in humans females. 
The posterior portion stores and releases two hypothalamic hormones:
1. Oxytocin: This stimulates powerful uterine contractions during labor and delivery of babies.
 It also causes milk ejection in nursing women. 
2. Antidiuretic hormone (ADH): This stimulates the kidney tubules to reabsorb and 
conserve water. This results in the production of small volumes of highly concentrated 
urine and decreased plasma osmolality. Underproduction leads to a condition 
called diabetes insipidus, where the affected person passes a lot of diluted urine.

Thyroid gland

It produces the thyroid hormone (TH), which includes thyroxine (T4) and triiodothyronine (T3).
 It increases the rate of cellular metabolism.
Calcitonin, is produced by the parafollicular cells of the thyroid gland. It decreases the blood
 calcium levels.

Parathyroid glands

It secretes parathyroid hormone (PTH), which causes an increase in blood calcium levels.

Pancreas

The pancreas is both an exocrine and an endocrine gland. Exocrine means that it
 has ducts.The endocrine portion (islets of langerhans) releases insulin and glucagon. 
It also releases smaller amounts of other hormones to the blood.
Glucagon, released by alpha (α) cells - It increases the glucose level in the blood.
Insulin is released by beta (β) cells - It reduces the glucose level in the blood. It increases
 the rate of glucose uptake and metabolism by most body cells. 

Gonads

The ovaries of the female release two main hormones - estrogens and progesterone.
 Estrogens stimulate maturation of the female reproductive system and development of 
the secondary sexual characteristics. Progesterone works with estrogens in establishing
 the menstrual cycle.
The testes of the male produce testosterone. It promotes maturation of the male reproductive
organs, development of secondary sex characteristics, and production of sperm by the testes.

Pineal gland

The pineal gland produces the hormone  melatonin, which influences daily rhythms such as
sleep and wake patterns.

Thymus 
It is an important organ of the immune system during the developmental stages of life.
It vanishes by the time of birth. The T-cells mature here.

No comments:

Post a Comment